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Murray Edwards College
University of Cambridge
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    Professor Christopher Huang

    01223 333822
    Murray Edwards College
    New Hall
    University of Cambridge
    Cambridge
    CB3 0DF

    Professorial Fellow in Medicine and Physiology; Director of Studies

    Medicine and Physiology

    Fellow

    I enjoy the academic collegiality with fellows in both medical and other subjects, as well as students who combine scientific and scholastic interests with their medical ones, in a relatively informal modern college setting.

    Degrees and honours

    • 1974: BA (Oxford), Final Honour School of Physiological Sciences, The Queen's College, Oxford.
    • 1976: BM BCh (Oxford). Clinical Medicine, Oxford University Clinical School.
    • 1979: PhD (Cambridge) Medical Research Council Scholar, Physiological Laboratory and Gonville and Caius College, Cambridge.
    • 1985: DM(Oxford)
    • 1986: MD(Cambridge)
    • 1995: DSc(Oxford)
    • 1995: ScD(Cambridge
    • 2011: FSB (United Kingdom)

    Awards and prizes:

    • Florence Heale Open Scholar, The Queen's College, Oxford.
    • 1971-76: President's Scholar, Republic of Singapore.
    • 1973: Benefactor's Prize, The Queen's College, Oxford.
    • 1976: Brian Johnson Prize in Pathology, University of Oxford.
    • 1977: LEPRA Award, British Leprosy Relief Association.
    • 1980: Rolleston Memorial Prize for Physiological Research, University of Oxford.
    • 1981: Gedge Prize in Physiology, University of Cambridge.
    • 2008-2011: Adjunct Professor, First Affiliated Hospital, Medical College, Xi’an Jiaotong University Medical Centre.

    Research interests

    Research into physiological signalling mechanisms, with the following outcomes:

    • 1978-1993: Demonstration and resolution of dielectric components of the activation signal in skeletal muscle excitation-contraction coupling.
    • 1988-1991: Novel methods of promoting clinical nerve regeneration through the use of freeze treated muscle grafts.
    • 1988-2004: Cellular signalling physiology regulating osteoclastic bone resorptive activity.
    • 1994-2002: Magnetic resonance imaging (MRI) analysis of cardiac changes in diabetes and hypertension, measurements of apparent diffusion coefficient, diffusion tensor and diffusion anisotropy in human brain tissue leading to MRI characterization of cortical spreading depression and physiological fMRI studies in hypoxic, hypercapnic and pharmacological in vivo systems
    • 1992-2008: Experimental and novel charge difference modeling studies of skeletal muscle osmotic and electrophysiological homeostasis
    • 1993-2006: Biophysical demonstration of allosteric dihydropyridine (DHPR)-ryanodine receptor (RyR) coupling.mechanisms in striated muscle.
    • 2000-present: Cardiac arrhythmic mechanisms in murine models of sudden adult cardiac death and atrial arrhythmias.

    Biography

    Employment history:

    • 1977-78: Pre-registration appointments: Nuffield Department of Medicine, University of Oxford [Prof. Sir D.J. Weatherall & Prof. J.G. Ledingham].
    • 1979-84: University Demonstrator in Physiology.
    • 1979-present: Fellow and College Lecturer in Physiology,
    • 1981-present: Director of Studies in Medical Sciences,
    • 2002-present: Professorial Fellow, Murray Edwards College, Cambridge.
    • 1984-96: University Lecturer in Physiology, Cambridge
    • 1996-2002: University Reader in Cellular Physiology, Cambridge.
    • 2002-present: Professor of Cell Physiology, University of Cambridge
    • 2006-present: Honorary Senior Research Fellow, Department of Biochemisty, University of Cambridge.
    • 2006-present: Independent non-executive director, chairman technical committee: Hutchison China Meditech UK.   committees:

    University committees:

    • 1986-present: Manager, Prince Philip Scholarship Fund, University of Cambridge.
    • 1988-present. Council of the Senate Joint Applications Committee
    • 2007-present: Adjudicator, Gedge Prize in Physiology, Cambridge University.
    • 2010-present: Convener and adjudicator for the William Bate Hardy Prize, Cambridge.

    National committees:

    • 2005-present: Editor: Biomedcentral Physiology.
    • 2007-present: Editor: Europace.
    • 2008-present: Editorial Board: Biological Reviews.
    • 2014-present: Fellowships Committee, British Heart Foundation UK.

    International committees:

    • 1990-96: Editor: The Journal of Physiology. 
    • 1994-99: Chairman: Editorial Board for Monographs of the Physiological Society.

    Selected Books:

    • Huang, C.L.-H. (1993). Intramembrane charge movements in striated muscle. Monographs of the Physiological Society, No. 44.  Oxford: Clarendon Press. 292 pp.
    • Glasby, M.A. & Huang, C.L-H. (Eds).  (1995). Applied Physiology for Surgery and Critical Care.  Butterworth-Heinneman. 756pp.
    • Usher-Smith, J. A., Murrell, G.A.C., Ellis, H.E. & Huang, C.L.-H. (2010). Research in Medicine: Planning a project – writing a thesis. 3/e.. Cambridge University Press.
    • Keynes, R. D., Aidley. D. J. & Huang, C. L-H. (2011). Nerve and Muscle 4/e. Cambridge University Press. ISBN: 9780521519557]
    • Chambers, D., Huang, C. L-H & Matthews, G.D.K. (2014). Basic Physiology for Anaesthetists. Cambridge University Press.

    Selected recent research papers

    • Martin, C. A., Guzadhur, L., Grace, A.A., Lei, M. & Huang, C. L-H. (2011). Mapping of reentrant spontaneous polymorphic ventricular tachycardia in a Scn5a+/- mouse model. American Journal of Physiology. Heart Circ Physiol. 300(5): H1853-1862. #H-00034-2011R2. PMID: 21378142
    • Hao, X., Zhang, Y., Zhang, X., Nirmalan, M., Davies, L., Konstantinou, D., Fei, T., Dobrzynski, H., Wang, X., Grace, A., Zhang, H., Boyett, M., Huang, C. L-H. & Lei, M. (2011). TGF-1 mediated fibrosis and ion channel remodeling are key mechanisms producing the sinus node dysfunction associated with SCN5A deficiency and aging. Circulation: Arrhythmia and Electrophysiology 4:397-406.  PMID:21493874
    • Fraser, J. A., Huang, C. L.-H.  & Pedersen, T. H. (2011). Relationships between resting conductances, excitability and t-system ionic homeostasis in skeletal muscle. Journal of General Physiology, 138:95-116. PMID: 21670205
    • Martin, C. A., Siedlecka, U., Kemmerich, K., Lawrence, J., Cartledge, J., Guzadhur, L., Brice, N., Grace, A. A., Schwiening, C., Terracciano, C. M. & Huang, C. L-H. (2012). Reduced Na+ and higher K+ channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/- mice. Open biology. 2,120072. [PMID: 22773948]
    • Matthews, G. D. K, Guzadhur, L., Sabir, I. N., Grace, A. A. & Huang, C.L-H. (2013). Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a+/- hearts. Journal of Physiology, 591, 4167-4188 [PMID: 23836691].
    • Wang, Y., Tsui, H., Ke, Y., Si, Y., Li, Y., Davies, L., Cartwright, E. J., Venetucci, L., Terrar, D. A., Zhang, H., Huang, C. L-H., Solaro, R. J., Wang, , & Lei, M., (2014). Pak1 is required to maintain ventricular Ca2+ homeostasis and electrophysiological stability through SERCA2a regulation in mice. Circulation Arrhythmia. 7:938-948. PMID: 25217043.

    Faculty website

    • Profile on the Department of Physiology, Development and Neuroscience website.