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Murray Edwards College
University of Cambridge
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    Dr Taufiq Rahman

    Murray Edwards College
    Cambridge
    CB3 0DF

    Fellow in Pharmacology

    Feeling much privileged and honoured to have just joined a vibrant, cosmopolitan and convivial community thriving within such an airy, bold and welcoming premises. Of many other things, I really admire the College's long standing role in encouraging and supporting promising young women for higher education and personal development and I look forward to being an active part of this exemplary initiative.

    Degrees and honours

    B.Pharm (DU, Bangladesh)

    M.Pharm (DU, Bangladesh)

    MSc (Manchester)

    PhD (Cantab)

    Awards and prizes

    Commonwealth Scholarship for pursuing MSc in 2003

    Yousef-Jameel Studentship for pursuing PhD in 2005

    Drapers Company Research Fellowship with Pembroke College in 2009

    Early Career Research Award in Signal Transduction by the Biochemical Society in 2011

    University Research Fellowship from the Royal Society in 2012

    Research interests

    I have interests in seemingly diverse themes but with essentially a 'small molecule-centric', chemical biology perspective. My group employs state-of-the art in silico approaches coupled with prospective, complementary wet experiments (calcium imaging, electrophysiology, biochemical and biophysical assays) to know the molecular mechanisms underlying the ligand recognition, ligand modulation, structural variation and evolution of some calcium-permeable ion channels. We are also pursuing rational development of novel chemical probes/modulators of these ion channels. Additionally, we are actively engaged in collaborative research for developing novel chemical scaffolds/leads against some protein targets implicated in microbial infections, cancer, pain and diabetes.

    Biography

    My early academic training was in pharmaceutical sciences with a Bachelor and Master of Pharmacy (B.Pharm and M.Pharm) degrees from the University of Dhaka, Bangladesh. My earlier research interests included ethnopharmacology and chemistry of bioactive natural products (I am still on it, in some ways!). After spending a year in Dhaka as a lecturer of pharmacy, I pursued an MSc in Molecular Pharmacology in the University of Manchester under the Commonwealth Scholarship and Fellowship program in 2003. In 2005, I came to Cambridge (as a member of Darwin College) to start a PhD with Professor Colin Taylor at the Department of Pharmacology. During this time, I studied biophysical properties and some regulatory aspects of inositol-1,4,5 trisphosphate receptors (IP3Rs), which are a major family of intracellular calcium channels. After finishing PhD in 2008, I continued research in the same lab as a post doc and then in October 2009, I started my first independent position as a Drapers’ Research Fellow at Pembroke College. Since October 2012, I started my own research group as a Royal Society University Research Fellow in the same Department and alongside this, I started a new position as a University Lecturer from April 2016.

    I am in the editorial board of the Biochemical Society Transactions and The Biochemical Journal (Portland Press) and In-silico Pharmacology (Springer) and have been a local ambassador of the Biochemical Society, UK. Previously, I served three years as a member in the Signal Transduction theme panel for the Biochemical Society. Recently, I have opted to be a mentor for the Destination STEMM initiative (http://www.windsor-fellowship.org/destination-stemm).

    Selected publications

    1.  Patel, S., Penny, C.J. and Rahman T (2016). Two-pore Channels Enter the Atomic Era: Structure of Plant TPC Revealed. Trends Biochem Sci. pii: S0968-0004(16)30025-1.

    2.  Chattopadhyay, A., O'Connor, C.J., Zhang, F., Galvagnion, C., Galloway, W.R., Tan, Y.S., Stokes, J.E., Rahman, T, Verma, C., Spring, D.R. and Itzhaki, L.S (2016). Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cell. Sci Rep.; 6:23732.

    3.  Rahman, T., Cai, X., Brailoiu, G.C., Abood, M.E., Brailoiu, E. and Patel, S (2014). Two-pore channels provide insight into the evolution of voltage-gated Ca2+ and Na+ channels. Science Signalling;7(352):ra109.

    4.  Rahman, T and Smith, E.S (2014). In silico assessment of interaction between sea anemone toxin APETx2 and Acid Sensing Ion Channel 3. Biochemical & Biophysical Research Communication. pii: S0006 291X(14)01019-5.

    5. Taylor, C.W., Tovey, S.C., Rossi, A.M., Lopez Sanjurjo, C.I., Prole D.L. and Rahman, T (2014).Structural organization of signalling to and from IP3 receptors. Biochemical Society Transactions;42(1):6370.

    6.  Ohene-Agyei, T., Mowla, R., Rahman, T. and  Venter, H (2014). Phytochemicals increase the antibacterial activity of antibiotics by acting on a drug efflux pump. Microbiologyopen ;3(6):885-96

    7.  Li, C., Enomoto, M., Rossi, A.M., Seo, M.D., Rahman, T., Stathopulos, P.B., Taylor, C.W., Ikura, M. and Ames, J.B. (2013). CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions. Proceedings of National Academy of Sciences USA 110 (21):8507-12.

    8.  Churamani, D., Hooper, R., Rahman, T., Brailoiu, E. and Patel, S. (2013). The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP. Biochemical Journal 453(1):147-51

    9.  Saleem, H., Tovey, S.C., Rahman, T., Riley, A.M., Potter, B.V. and Taylor CW. (2013). Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3. PLoS One 8(1):e54877

    10.  Sun, Y., Rossi, AM., Rahman, T. and Taylor, C.W. (2012).  Activation of IP3 receptors requires an endogenous 1-8-14 calmodulin-binding motif. Biochemical Journal 449: 39-49.

    11.  Rahman, T. (2012). Dynamic clustering of IP3 receptor by IP3. Biochemical Society Transduction 40:325-330.

    12.  Patel, S., Ramakrishnan, L., Rahman, T., Hamdoun, A., Marchant, J. S., Taylor, C. W., and Brailoiu,E. (2011). The endo-lysosomal system as an NAADP-sensitive acidic Ca2+ store: role for the two-pore channels. Cell Calcium 50, 157-167.

    13.  Brailoiu, E., Rahman, T., Churamani, D., Prole, D. L., Brailoiu, G. C., Hooper, R., Taylor, C. W., and Patel, S. (2010). An NAADP-gated two-pore channel targeted to the plasma membrane uncouples triggering from amplifying Ca2+ signals. Journal of Biological Chemistry 285, 38511-38516.

    14. Rahman, T., and Rahmatullah, M. (2010). Proposed structural basis of interaction of piperine and related compounds with monoamine oxidases. Bioorganic and Medicinal Chemistry Letters 20, 537-540.

    15.  Ding, Z., Rossi, A. M., Riley, A. M., Rahman, T., Potter, B. V., and Taylor, C. W. (2010). Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand. Molecular Pharmacology 77, 995-1004.

    16.  Tovey, S. C., Dedos, S. G., Rahman, T., Taylor, E. J., Pantazaka, E., and Taylor, C. W. (2010). Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP dependent protein kinase. Journal of Biological Chemistry 285, 12979-12989.

    17.  Rahman, T., Skupin, A., Falcke, M., and Taylor, C. W. (2009). Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+. Nature 458, 655-659.

    18.  Rossi, A. M., Riley, A. M., Tovey, S. C., Rahman, T., Dellis, O., Taylor, E. J., Veresov, V. G., Potter, B. V., and Taylor, C. W. (2009). Synthetic partial agonists reveal key steps in IP3 receptor activation. Nature Chemical Biology 5, 631-639.

    19. Taylor, C. W., Prole, D. L., and Rahman, T. (2009). Ca2+ channels on the move. Biochemistry 48, 12062-12080.

    20.  Dellis, O., Dedos, S. G., Tovey, S. C., Taufiq Ur, R., Dubel, S. J., and Taylor, C. W. (2006). Ca2+ entry through plasma membrane IP3 receptors. Science 313, 229-233.

    Book

    Rahmatullah, M.; Jahan, R and Rahman, T.(2016). Compendium of Bangladesh Folk and Tribal Medicinal Plants, Volume-1. A H Development Publishing House, Bangladesh.