Postdoctoral Bye Fellow in Physiology, Development and Neuroscience
Physiology, Development and Neuroscience
Murray Edwards is a welcoming and vibrant place and I am delighted to be part of its inspirational and dynamic community.
Degrees and Honours
Borysiewicz Biomedical Sciences Fellow
Associate Fellow of the UK Higher Education Academy
PhD (Life Sciences), National Centre for Biological Sciences (NCBS),
Tata Institute of Fundamental Research (TIFR), Bangalore, India
BSc (Honours) Biochemistry, University of Delhi, India
Current Research Interests
- Genetic causes of obesity
- Neuronal regulation of energy homeostasis
- Inter-organ communication in metabolism
Dr. Agrawal did her PhD from the National Centre for Biological Sciences (NCBS), Bangalore, India where she studied the role of neuronal calcium signalling in regulating cellular processes that modulate behaviour. She then moved to the Institute of Biology Valrose, Nice, France where she explored the fundamental question of how nutritional information is sensed and communicated systemically to regulate body size. She is now a Postdoctoral Research Associate at the Gurdon Institute where she is working on a project to understand the genetic basis of perturbations in neuronal energy homeostasis that result in obesity, in collaboration with the Institute of Metabolic Science, University of Cambridge.
Dr. Agrawal has an active interest in science education and outreach and has volunteered at various educational organisations. She was also a visiting fellow at the Homi Bhabha Centre for Science Education (HBCSE), TIFR, Mumbai, India, the premier institute in India for research and development in science education, where she examined a ‘Systems Thinking’ approach in education.
Delanoue R, Meschi E*, Agrawal N*, Mauri A, Tsatskis Y, McNeill H, Léopold P. Drosophila insulin release is triggered by adipose Stunted ligand to brain Methuselah receptor. *Equal contributions. Science; 2016 Sep 30;353(6307):1553-1556.
Agrawal N, Delanoue R, Mauri A, Basco D, Pasco M, Thorens B, Léopold P. The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response. Cell Metabolism; 2016 Apr 12;23(4):675-84.
Agrawal N and Leopold P. Hedgehog turns into a metabolic hormone. Current Biology; 2015 Feb 2; 25(3): R117-9.
Agrawal N and Hasan, G. Drosophila InsP3R mutants and their effects on cellular and systemic physiology. Wiley Interdisciplinary Reviews: Membrane Transport and Signaling; 2012; 1: 70-77. Invited review.
Agrawal N*, Venkiteswaran G*, Sadaf S, Padmanabhan N, Banerjee S and Hasan G. Inositol 1,4,5-trisphosphate receptor and dSTIM function in Drosophila insulin producing neurons regulates systemic intracellular calcium homeostasis and flight. *Equal contributions. Journal of Neuroscience; 2010 January 27; 30(4):1301–1313.
Agrawal N, Padmanabhan N and Hasan G. Inositol 1,4,5-trisphosphate Receptor Function in Drosophila Insulin Producing Cells. PLoS ONE; 2009 Aug 14; 4(8): e6652.
Nair S, Agrawal N, Hasan G. Homeostasis of glutamate neurotransmission is altered in Drosophila Inositol 1,4,5-trisphosphate receptor mutants. Invertebrate Neuroscience; 2007 Sep; 7(3):137-47.
Banerjee S, Joshi R, Venkiteswaran G, Agrawal N, Srikanth S, Alam F, Hasan G. Compensation of inositol 1,4,5-trisphosphate receptor function by altering sarco-endoplasmic reticulum calcium ATPase activity in the Drosophila flight circuit. Journal of Neuroscience; 2006 Aug 9; 26(32):8278 -88.