Top login menu

Murray Edwards College
University of Cambridge
  • Home
  • Main page content

    Dr David Shorthouse

    Department of Pharmacology
    Tennis Court Road
    CB2 1PD

    Postdoctoral Bye Fellow in Biochemistry

    Natural Sciences (Biological)

    Bye fellow


    • Bsc(Hons)
    • DPhil

    Research Interests:    

    David works in cancer research and has a background in biochemistry and molecular biology. David specialises in treatment targeting and repurposing in cancers of the gastrointestinal tract. His research aims are the better directing of current cancer treatments to patients who are most likely to respond well to them, and exploring the use of common drugs such as antidepressants and antiepileptics in oncology.

    David is a member of the Cambridge Department of Pharmacology and the UCL Department of Biomedical Engineering, and works closely with the CRUK Cambridge Institute and the Cambridge Early Cancer Institute.

    David currently teaches on the NST Mathematical Biology and Biology of Cells courses, the MedST/VetST Molecules in Medical Science courses, the Part II Pharmacology course, and the Part III Systems Biology course.


    David completed his DPhil in the Department of Biochemistry at the University of Oxford where he worked on methods for improving the manufacturing and design of monoclonal antibodies – proteins used heavily in immunotherapies for a number of diseases. He then moved to the University of Cambridge and joined the MRC Cancer Unit, where he studied how ion channels (proteins involved in maintaining the polarity and charge of a cell) impact cancer prognosis and metastasis. In 2020 he became a member of the Department of Pharmacology, and a member of the UCL Department of Biomedical Engineering and Medical Physics.


    • Shorthouse D, Bradley J, Critchlow S, Bendtsen C, Hall B A, Heterogeneity of the Cancer Cell Line Metabolic Landscape. Molecular Systems Biology, (2022).
    • Rahrmann E, Shorthouse D, Jassim A, Hu L, Ortiz M, Mahler-Araujo B, Vogel P, Thiruvenkatam R, Blundon J, Kay J, Nazarian R, Hall B, Zakharenjo S, Winton D, Zhi L, Gilbertson R. NALCN Regulates Malignant and Non-Malignant Metastasis. Nature Genetics, (2022).
    • Talarmain L, Clarke M, Cabrera Cosbe L, Shorthouse D, Fisher J, Kent. D, Hall B.A, HOXA9 has the hallmarks of a sequential logic gate, with implications for acute myeloid leukaemia and myeloproliferative neoplasms. Nature Communications, (2022).
    • Riedel A, Helal M, Pedro L, Swietlik J, Shorthouse D, Schmitz W, Haas L, Young T, da Costa A, Davidson S, Bhandare P, Wolf E, Hall B, Oskarsson T, Shields J. Tumor-Derived Lactic Acid Modulates Activation and Metabolic Status of Draining Lymph Node Stroma. Cancer Immunology Research, (2022).
    • Shorthouse D, Hall B.A, SARS-CoV-2 Variants are Selecting for Spike Protein Mutations that Increase Protein Stability. Journal of Chemical Information and Modelling, (2021).
    • Shorthouse D, Hall M, Hall B.A, Computational Saturation Screen Reveals the Landscape of Mutations in Human Fumarate Hydratase. Journal of Chemical Information and Modelling, (2021).
    • Lee M, Shorthouse D, Hall B, Venkitaraman A, Cancer-causing BRCA2 missense mutations disrupt an intracellular protein assembly mechanism to disable genome maintenance. Nucleic Acids Research, (2021).
    • Fowler J, King C, Bryant C, Hall M, Sood R, Ong S, Earp E, Fernandez-Antoran D, Koeppel J, Dentro S, Shorthouse D, Durrani A, Fife K, Rytina E, Milne D, Roshan A, Mahububani K, Saeb-Parsy K, Hall B A, Gerstung M and Jones P H, Selection of oncogenic mutant clones in normal skin varies with body site. Cancer Discovery, (2020).
    • Hall M, Shorthouse D, Jones P H, Hall B A, Darwinian Shift: A General Approach for Establishing Evidence and Mechanism of Natural Selection. Biophysical Journal, (2020).
    • Shorthouse D, Riedel A, Kerr E, Martins C, Shields J & Hall B.A, Exploring the Role of Stromal Osmoregulation in Cancer and Disease using Executable Modelling. Nature Communications (2018).
    • Paterson Y#, Shorthouse D#, Pleijzier M#, Piterman N, Bendtsen C, Hall B.A, Fisher J, A toolbox for discrete modelling of cell signaling dynamics. International Journal of Integrative Biology (2018). #signifies joint contribution
    • Turrell FK, Kerr EM, Gao M, Thorpe H, Doherty GJ, Cridge J, Shorthouse D, Speed A, Samarajiwa S, Hall BA, Griffiths M, Martins CP, Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity. Genes & Development (2017).
    • Shorthouse D, Riedel A, Shields J, Hall B.A, Deregulation of Osmotic Machinery Explains and Predicts Cellular Transformation in Cancer and Disease. Lecture Notes in Computer Science (2016).
    • Riedel A, Shorthouse D, Haas L, Hall B.A & Shields J, Tumor-induced Stromal Reprogramming Drives Lymph Node Transformation. Nature Immunology (2016).
    • Hedger G, Shorthouse D, Koldsoe H, Sansom M.S.P, Free Energy Landscape of Lipid Interactions with Regulatory Binding Sites on the Transmembrane Domain of the EGF Receptor. Journal of Physical Chemistry B (2016).
    • Shorthouse D, Hedger G, Koldsoe H, Sansom M.S.P, Invited Article: Computational Studies of Glycolipids – Towards more Complex Membrane Models. Biochimie (2015).
    • Reddy T, Shorthouse D, Parton D, Jefferys E, Fowler P, Chavent M, Baaden M, Sansom M.S.P, Nothing to Sneeze at: a Dynamic and Integrative Computational Model of an Influenza A Virion. Structure (2015).
    • Koldsoe H, Shorthouse D, Heile J, Sansom M.S.P, Lipid Clustering Correlates with Membrane Curvature as Revealed by Molecular Simulations of Complex Lipid Bilayers. PLOS Computational Biology (2014).